Bioengineering

The Bioengineering PhD program combines existing expertise in Chemical and Biochemical Engineering with 10 allied engineering and science departments (Biological Sciences, Chemical Engineering, Chemistry, Computer Science, Civil Engineering, Electrical Engineering, Engineering Management, Materials Science and Engineering, Mechanical Engineering, and Math) spanning three colleges (the College of Engineering and Computing, the College of Arts, Sciences, and Education, and the Kummer College of Innovation, Entrepreneurship, and Economic Development) at Missouri S&T to achieve the following objectives,

  1. To attract a large and diverse set of students.
  2. To build a highly skilled workforce in bioengineering to meet the current and emergent needs of industries, regulatory agencies, and NGOs.
  3. To serve as an integrator and catalyst for faculty members at Missouri S&T to discover new ideas, develop collaborations, and increase scholarly productivity in the critically important bioengineering research domain.
  4. To build research and educational collaborations with industry and other external partners, including those within the UM system. This includes supporting existing focus areas such as precision medicine.

The PhD is open to interested students from relevant engineering and science backgrounds, but is primarily focused on those with a BS or MS degree in Chemical Engineering, Biochemical Engineering, Biomedical Engineering, Biomolecular Engineering, or Biological Engineering.  The successful applicant must have minimum undergraduate grade point average of 3.0/4.0 or equivalent and strong letters of recommendations.

Students who enter the program directly with a BS degree will need to complete a minimum of 72 credit hours beyond BS degree, which should include a minimum of 30 credit hours of 4000-, 5000-, and 6000-level lecture courses. A student entering with a MS degree will receive a block of 30 credit hours toward the total 72-hour program requirement and must complete a minimum of 24 credit hours of graduate research and a minimum of 12 credit hours of 4000-, 5000-, and 6000-level lecture courses.  In addition, the PhD students are required to pass a PhD qualifying exam before their 5th semester and a PhD comprehensive exam after completing at least 50% of their required coursework for the PhD degree. They must conduct research, write a PhD dissertation, and successfully defend the dissertation in their final examination (defense).

Core Courses: select a minimum of 9 credit hours from the following courses
BME 5100Drug and Gene Delivery Systems Drug and Gene Delivery3
BME 6400Biomanufacturing Biomanufacturing3
BME 6500Pharmaceutical Process Engineering Pharmaceutical Process Engineering3
CHEM ENG 5250Isolation and Purification of Biologicals3
MS&E 5310Biomaterials I3
Ethics: required
BME 5311Integrity and Ethics in Bioengineering Integrity and Ethics in Bioengineering1
Lecture Series: enroll at least twice
CHEM ENG 6015Lecture Series1
Elective Courses: select a minimum of 18 credit hours from the following courses
Biomanufacturing and Biochemical Engineering Process Design
BME 5100Drug and Gene Delivery Systems Drug and Gene Delivery3
CHEM ENG 4210Biochemical Reactors3
CHEM ENG 4220Biochemical Reactor Laboratory3
CHEM ENG 5100Intermediate Transport Phenomena3
CHEM ENG 5120Interfacial Phenomena In Chemical Engineering3
CHEM ENG 5150Intermediate Process Computing3
CHEM ENG 5161Intermediate Molecular Engineering3
CHEM ENG 5210Intermediate Biochemical Reactors3
CHEM ENG 5211Intermediate Bioreactor Laboratory Intermediate Bioreactor Laboratory3
CHEM ENG 5220Intermediate Engineering Thermodynamics3
CHEM ENG 5250Isolation and Purification of Biologicals3
CHEM ENG 5251Intermediate Bioseparations Laboratory Intermediate Bioseparations Laboratory3
MS&E 5310Biomaterials I3
Biomaterials and Tissue Engineering
CHEM ENG 5300Principles Of Engineering Materials3
CHEM ENG 5320Introduction to Nanomaterials3
CHEM ENG 6150Molecular Modeling and Simulation3
CHEM ENG 6300Biomaterials II3
ELEC ENG 5810Computational Intelligence3
ELEC ENG 6260Integrated Microsystems Engineering3
MECH ENG 5229Smart Materials and Sensors3
MS&E 5210Tissue Engineering 3
MS&E 5460Molecular Engineering of Materials3
MS&E 6210Advanced Tissue Engineering3
MS&E 6460Advanced Molecular Engineering of Materials3
ENV ENG 6601Biological Principles In Environmental Engineering Systems3
ENV ENG 6612Biological Operations In Environmental Engineering Systems3
Data Analysis and Computational Modeling
STAT 5346Regression Analysis3
STAT 6344Design And Analysis Of Experiments3
COMP SCI 5401Evolutionary Computing3
COMP SCI 5700Bioinformatics3
Biochemical Interactions and Applications in Medicine and Nanotechnology
CHEM 5001Special Topics Medicinal Chemistry3
CHEM 5610Biochemistry3
CHEM 5620Biochemical Metabolism3
CHEM 5630Biochemical Nanotechnology3
BIO SCI 5533Pharmacology3
BIO SCI 6413Molecular Cell Biology3
BIO SCI 6523Advanced Biomolecules3
BIO SCI 6666Advanced Nanotechnology in Biomedicine3

BME 5001 Special Topics (LAB 0.0 and LEC 0.0)

This course is designed to give the department an opportunity to test a new course. Variable titles.


BME 5100 Drug and Gene Delivery Systems (LEC 3.0)

Overview of drug and gene delivery systems, rational design for their applications with an emphasis on structure-property-function relationships. Three major parts: polymers and nanoparticles as drug and gene carriers; strategies to deliver drugs and genes; in vitro and in vivo techniques of assessment and validation. Prerequisites: Chem 2210 and Bio Sci 2213.


BME 5200 Materials as Hard Tissue Devices (LEC 3.0)

The structure-property relationships of materials employed as medical devices, as well as the bone, cartilage, and ligament that they are designed to replace. The behavior of materials in the physiological environment, the tailoring of that behavior as a response to both bulk and surface properties, and the future of hard tissue medical devices. Prerequisites: BME 4100 or MS&E 5210.


BME 5300 Vaccine Manufacturing (LEC 3.0)

The development, manufacturing, and approval process of vaccines are covered. Vaccines that use attenuated or inactivated viruses, viral components and mRNA as the active ingredient are discussed. The manufacturing process includes the making of the active ingredient, vaccine formulation and delivery. The class includes three remote lab experiments. Prerequisites: Senior standing in an engineering discipline, physics, chemistry, or biology.


BME 5311 Integrity and Ethics in Bioengineering (LEC 1.0)

Study of ethical, social, and legal issues that arise in biotechnology and pharmaceutical industries and in biomedical research. Emphasis on professional attitudes and standard practices. Prerequisites: Senior or graduate standing.


BME 6400 Biomanufacturing (LEC 3.0)

The development, production, recovery, and analysis of biorelated products. Specific topics include biomaterial synthesis and characterization, cell culture, bioreactor design and operation, production and purification process development, and regulatory expectations. Prerequisites: graduate standing.


BME 6500 Pharmaceutical Process Engineering (LEC 3.0)

The manufacture, extraction, processing, purification, formulation/filling, and packaging of pharmaceutical materials to be used as medications for humans or animals. The major manufactured products and their principal manufacturing steps will be covered. The principles of engineering operations and scale-up process in pharmaceutical industry will be discussed together with quality control, pollution prevention, and Good Manufacturing Practices (GMP). Prerequisites: Chem Eng 5250.